Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond

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dc.creatorSiddik, Md Abu
dc.creatorShin, Andrew C. (TTU)
dc.date.accessioned2022-05-12T18:47:03Z
dc.date.available2022-05-12T18:47:03Z
dc.date.issued2019
dc.description© 2019 Korean Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractBranched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in our body; thus, they need to be obtained from food. They have shown to provide many physiological and metabolic benefits such as stimulation of pancreatic insulin secretion, milk production, adipogenesis, and enhanced immune function, among others, mainly mediated by mammalian target of rapamycin (mTOR) signaling pathway. After identified as a reliable marker of obesity and type 2 diabetes in recent years, an increasing number of studies have surfaced implicating BCAAs in the pathophysiology of other diseases such as cancers, cardiovascular diseases, and even neurodegenerative disorders like Alzheimer's disease. Here we discuss the most recent progress and review studies highlighting both correlational and potentially causative role of BCAAs in the development of these disorders. Although we are just beginning to understand the intricate relationships between BCAAs and some of the most prevalent chronic diseases, current findings raise a possibility that they are linked by a similar putative mechanism.en_US
dc.identifier.citationSiddik, M. A. B., & Shin, A. C. (2019). Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond. Endocrinol Metab, 34(3), 234-246. https://doi.org/10.3803/EnM.2019.34.3.234en_US
dc.identifier.urihttps://doi.org/10.3803/EnM.2019.34.3.234
dc.identifier.urihttps://hdl.handle.net/2346/89185
dc.language.isoengen_US
dc.subjectBranched-Chain Amino Acidsen_US
dc.subjectMetabolismen_US
dc.subjectCancersen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectHeart Failureen_US
dc.titleRecent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyonden_US
dc.typeArticleen_US

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