Effects of l-theanine–caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT

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dc.creatorKahathuduwa, Chanaka N. (TTUHSC) (TTUHSC) (TTU)
dc.creatorWakefield, Sarah (TTUHSC) (TTU)
dc.creatorWest, Blake D. (TTU)
dc.creatorBlume, Jessica (TTU)
dc.creatorDassanayake, Tharaka L.
dc.creatorWeerasinghe, Vajira S.
dc.creatorMastergeorge, Ann (TTU)
dc.date.accessioned2023-04-03T17:18:30Z
dc.date.available2023-04-03T17:18:30Z
dc.date.issued2020
dc.description© 2020, The Author(s). cc-by
dc.description.abstractWe examined the acute effects of l-theanine, caffeine and their combination on sustained attention, inhibitory control and overall cognition in boys with attention deficit hyperactivity disorder (ADHD). l-Theanine (2.5 mg/kg), caffeine (2.0 mg/kg), their combination and a placebo were administered in a randomized four-way repeated-measures crossover with washout, to five boys (8–15 years) with ADHD. Functional magnetic resonance imaging (fMRI) was performed during a Go/NoGo task and a Stop-signal task ~ 1 h post-dose. NIH Cognition Toolbox was administered ~ 2 h post-dose. Treatment vs. placebo effects were examined in multi-level mixed-effects models. l-Theanine improved total cognition composite in NIH Cognition Toolbox (p = 0.040) vs. placebo. Caffeine worsened and l-theanine had a trend of worsening inhibitory control (i.e. increased Stop-signal reaction time; p = 0.031 and p = 0.053 respectively). l-Theanine–caffeine combination improved total cognition composite (p = 0.041), d-prime in the Go/NoGo task (p = 0.033) and showed a trend of improvement of inhibitory control (p = 0.080). l-Theanine–caffeine combination was associated with decreased task-related reactivity of a brain network associated with mind wandering (i.e. default mode network). l-Theanine–caffeine combination may be a potential therapeutic option for ADHD-associated impairments in sustained attention, inhibitory control and overall cognitive performance.
dc.identifier.citationKahathuduwa, C.N., Wakefield, S., West, B.D., Blume, J., Dassanayake, T.L., Weerasinghe, V.S., & Mastergeorge, A.. 2020. Effects of l-theanine–caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-70037-7
dc.identifier.urihttps://doi.org/10.1038/s41598-020-70037-7
dc.identifier.urihttps://hdl.handle.net/2346/92437
dc.language.isoeng
dc.titleEffects of l-theanine–caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT
dc.typeArticle

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