Prevalence and related factors of anxiety in first episode and drug naïve Chinese Han outpatients with psychotic major depression

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dc.creatorZhou, Yanan
dc.creatorWang, Qianjin
dc.creatorRen, Honghong
dc.creatorYang, Winson Fu Zun (TTU)
dc.creatorMa, Yuejiao
dc.creatorWu, Qiuxia
dc.creatorLuo, Yinli
dc.creatorYang, Dong
dc.creatorLiu, Tieqiao
dc.creatorZhang, Xiangyang
dc.date.accessioned2023-01-10T21:20:07Z
dc.date.available2023-01-10T21:20:07Z
dc.date.issued2022
dc.description© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.description.abstractBackground: Anxiety frequently occurs with major depressive disorder (MDD) but to a different extent in the various subtypes. Psychotic major depression (PMD) is a severe subtype of MDD that is under-identified and under-studied. We investigated the prevalence and related risk factors of anxiety in PMD patients. Methods: A total of 1718 first episode and drug naïve MDD patients were recruited. Measures included the Hamilton Depression Scale (HAMD), Clinical Global Impression-Severity scale (CGI-S), Hamilton Anxiety Scale (HAMA), and positive symptom scale of the Positive and Negative Syndrome Scale (PANSS), thyroid hormone levels, and metabolic parameters. Results: 171 of the entire MDD study sample met the criteria for the PMD subtype. The prevalence of severe anxiety was much higher in PMD patients (22.8 %) than in non-PMD patients (0.4 %) (χ2 = 294.69, P < 0.001, OR = 75.88, 95 % CI = 31.55–182.52). Compared to PMD patients without severe anxiety, PMD patients with severe anxiety had higher HAMD score, CGI-S score, positive symptom subscale score, suicide attempts, blood pressure, thyroid-stimulating hormone (TSH), anti-thyroglobulin (TgAb), and thyroid peroxidases antibody (TPOAb) levels. Furthermore, logistic regression analysis indicated that HAMD score and TSH levels were associated with severe anxiety in PMD patients. Limitations: Our cross-sectional study cannot explain the causal relationship between anxiety severity and risk factors in PMD patients. Conclusions: Our results suggest that PMD patients are more likely to experience severe anxiety than non-PMD patients. The severity of depression and TSH levels are independent risk factors for anxiety in PMD patients.en_US
dc.identifier.citationZhou, Y., Wang, Q., Ren, H., Yang, W. F. Z., Ma, Y., Wu, Q., Luo, Y., Yang, D., Liu, T., & Zhang, X. (2022). Prevalence and related factors of anxiety in first episode and drug naïve Chinese Han outpatients with psychotic major depression. Journal of Affective Disorders, 316, 217-222. https://doi.org/10.1016/j.jad.2022.08.018en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2022.08.018
dc.identifier.urihttps://hdl.handle.net/2346/90454
dc.language.isoengen_US
dc.subjectAnxietyen_US
dc.subjectDepressionen_US
dc.subjectPsychotic Symptomen_US
dc.subjectThyroid-Stimulating Hormoneen_US
dc.titlePrevalence and related factors of anxiety in first episode and drug naïve Chinese Han outpatients with psychotic major depressionen_US
dc.typeArticleen_US

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