Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes

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dc.creatorChen, Yan
dc.creatorTan, George Z. (TTU)
dc.creatorZhou, Yingge
dc.date.accessioned2022-08-31T15:35:42Z
dc.date.available2022-08-31T15:35:42Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.description.abstractVascularization for tissue engineering applications has been challenging over the past decades. Numerous efforts have been made to fabricate artificial arteries and veins, while few focused on capillary vascularization. In this paper, core-sheath electrospinning was adopted to fabricate nanoporous microtubes that mimic the native capillaries. The results showed that both solution viscosity and polyethylene oxide (PEO) ratio in polycaprolactone (PCL) sheath solution had significant effects on microtube diameter. Adding PEO into PCL sheath solution is also beneficial to surface pore formation, although the effects of further increasing PEO showed mixed results in different viscosity groups. Our study showed that the high viscosity group with a PCL/PEO ratio of 3:1 resulted in the highest average microtube diameter (2.14 µm) and pore size (250 nm), which mimics the native human capillary size of 1–10 µm. Therefore, our microtubes show high potential in tissue vascularization of engineered scaffolds.en_US
dc.identifier.citationChen Y, Tan GZ, Zhou Y. Effects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubes. Polymers. 2021; 13(21):3650. https://doi.org/10.3390/polym13213650en_US
dc.identifier.urihttps://doi.org/10.3390/polym13213650
dc.identifier.urihttps://hdl.handle.net/2346/90092
dc.language.isoengen_US
dc.subjectCore-Sheath Electrospinningen_US
dc.subjectNanoporous Microtubesen_US
dc.subjectTissue Engineeringen_US
dc.subjectAdvanced Manufacturingen_US
dc.titleEffects of Viscosities and Solution Composition on Core-Sheath Electrospun Polycaprolactone(PCL) Nanoporous Microtubesen_US
dc.typeArticleen_US

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