Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

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dc.creatorXie, An
dc.creatorWu, Qiuxia (TTU)
dc.creatorYang, Winson Fu Zun (TTU)
dc.creatorQi, Chang
dc.creatorLiao, Yanhui
dc.creatorWang, Xuyi
dc.creatorHao, Wei
dc.creatorTang, Yi-Yuan (TTU)
dc.creatorLiu, Jianbin
dc.creatorLiu, Tieqiao
dc.creatorTang, Jinsong
dc.date.accessioned2022-06-30T18:04:32Z
dc.date.available2022-06-30T18:04:32Z
dc.date.issued2021
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author (s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.description.abstractMethamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (nā€‰=ā€‰70) and healthy controls (HCs) (nā€‰=ā€‰84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.en_US
dc.identifier.citationXie, A., Wu, Q., Yang, W.F.Z. et al. Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users. Sci Rep 11, 7705 (2021). https://doi.org/10.1038/s41598-021-87185-zen_US
dc.identifier.urihttps://doi.org/10.1038/s41598-021-87185-z
dc.identifier.urihttps://hdl.handle.net/2346/89894
dc.language.isoengen_US
dc.subjectMedical Researchen_US
dc.subjectNeuroscienceen_US
dc.titleAltered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent usersen_US
dc.typeArticleen_US

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