Soluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity

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dc.creatorOverby, Haley
dc.creatorYang, Yang
dc.creatorXu, Xinyun
dc.creatorGraham, Katherine
dc.creatorHildreth, Kelsey
dc.creatorChoi, Sue
dc.creatorWan, Debin
dc.creatorMorisseau, Christophe
dc.creatorZeldin, Darryl C.
dc.creatorHammock, Bruce D.
dc.creatorWang, Shu (TTU)
dc.creatorBettaieb, Ahmed
dc.creatorZhao, Ling
dc.date.accessioned2023-04-14T18:12:49Z
dc.date.available2023-04-14T18:12:49Z
dc.date.issued2020
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. cc-by
dc.description.abstractBrown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipogenesis and BAT activity in treating diet-induced obesity (DIO) have not been reported. sEH expression was studied in in vitro models of brown adipogenesis and the fat tissues of DIO mice. The effects of the sEHI, trans-4-{4-[3-(4-trifluoromethoxy-phenyl)ureido]-cyclohexyloxy-benzoic acid (t-TUCB), were studied in vitro and in the obese mice via mini osmotic pump delivery. sEH expression was increased in brown adipogenesis and the BAT of the DIO mice. t-TUCB promoted brown adipogenesis in vitro. Although t-TCUB did not change body weight, fat pad weight, or glucose and insulin tolerance in the obese mice, it decreased serum triglycerides and increased protein expression of genes important for lipid metabolism in the BAT. Our results suggest that sEH may play a critical role in brown adipogenesis, and sEHI may be beneficial in improving BAT protein expression involved in lipid metabolism. Further studies using the sEHI combined with EpFA generating diets for obesity treatment and prevention are warranted.
dc.identifier.citationOverby, H., Yang, Y., Xu, X., Graham, K., Hildreth, K., Choi, S., Wan, D., Morisseau, C., Zeldin, D.C., Hammock, B.D., Wang, S., Bettaieb, A., & Zhao, L.. 2020. Soluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity. International Journal of Molecular Sciences, 21(19). https://doi.org/10.3390/ijms21197039
dc.identifier.urihttps://doi.org/10.3390/ijms21197039
dc.identifier.urihttps://hdl.handle.net/2346/92816
dc.language.isoeng
dc.subjectBrown adipogenesis
dc.subjectBrown adipose tissue
dc.subjectSoluble epoxide hydrolase
dc.subjectSoluble epoxide hydrolase inhibitor
dc.subjectT-TUCB
dc.titleSoluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity
dc.typeArticle

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