Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial
dc.creator | Jäger, Ralf | |
dc.creator | Purpura, Martin | |
dc.creator | Davis, Jaci | |
dc.creator | Keratsopoulos, Nikolas | |
dc.creator | Parra, Mandy E. | |
dc.creator | Secrest, Ariane H. | |
dc.creator | Tinsley, Grant M. (TTU) | |
dc.creator | Taylor, Lem | |
dc.date.accessioned | 2024-05-16T19:43:35Z | |
dc.date.available | 2024-05-16T19:43:35Z | |
dc.date.issued | 2024 | |
dc.description | cc-by | |
dc.description.abstract | Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion. GPM zinc concentrations were significantly higher at 120 min (p = 0.02; 12.4 ± 5.1 mcg/dL), 180 min (p = 0.002; 16.8 ± 5.1 mcg/dL), and 240 min (p = 0.007; 14.6 ± 5.1 mcg/dL) in comparison to USP zinc oxide. In addition, GPM zinc significantly increased iAUC by 40% (5840 ± 2684 vs. 4183 ± 1132 mcg/dL * 480 min, p = 0.02), and Cmax values were 10% higher in GPM compared to USP (148 ± 21 mcg/dL vs. 135 ± 17.5 mcg/dL, p = 0.08). Tmax was 12% slower in GPM compared to USP (112.5 ± 38.7 min vs. 127.5 ± 43.1 min); however, differences in Tmax failed to reach statistical significance (p = 0.28). Zinc bound to a glycoprotein matrix significantly increased absorption compared to zinc oxide. | |
dc.identifier.citation | Jager, R., Purpura, M., Davis, J., Keratsopoulos, N., Parra, M.E., Secrest, A.H., Tinsley, G.M., & Taylor, L.. 2024. Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial. Nutrients, 16(7). https://doi.org/10.3390/nu16071012 | |
dc.identifier.uri | https://doi.org/10.3390/nu16071012 | |
dc.identifier.uri | https://hdl.handle.net/2346/98120 | |
dc.language.iso | eng | |
dc.subject | absorption | |
dc.subject | postbiotic | |
dc.subject | whole-food nutrients | |
dc.subject | zinc | |
dc.title | Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial | |
dc.type | Article |
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