Comparison of Thyroid Hormone Levels Between Patients With Major Depressive Disorder and Healthy Individuals in China

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dc.creatorZhou, Yanan
dc.creatorMa, Yuejiao
dc.creatorWu, Qiuxia
dc.creatorWang, Qianjin
dc.creatorYang, Winson Fu Zun (TTU)
dc.creatorWang, Yunfei
dc.creatorYang, Dong
dc.creatorLuo, Yinli
dc.creatorTang, Kewei
dc.creatorLiu, Tieqiao
dc.creatorWang, Dongfang
dc.date.accessioned2022-09-15T17:15:27Z
dc.date.available2022-09-15T17:15:27Z
dc.date.issued2021
dc.description© 2021 Zhou, Ma, Wu, Wang, Yang, Wang, Yang, Luo, Tang, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.description.abstractAbnormal thyroid function in major depressive disorder (MDD) has been studied extensively, but the results still remain inconsistent. In China, few large-scale studies have investigated the differences in the levels of thyroid hormones between patients with MDD and healthy controls (HCs). In this retrospective, cross-sectional study, 535 MDD patients and 998 HCs were included. We compared the levels of thyroid hormones (FT3, FT4, and TSH) between the two groups, as well as investigated the distribution of levels of thyroid hormones within and outside normal ranges. The results showed that all the three hormones were significantly lower in MDD patients than in HCs, which was also true in different gender and age subgroups. The proportion of subjects with levels of all the three hormones outside the normal range in the MDD group was higher than that in the HC group (all p < 0.05). However, no significant difference was found in clinical/subclinical hyperthyroidism or hypothyroidism between the two groups (p > 0.05). Our study showed that the levels of thyroid hormones were lower in MDD patients, suggesting that there was an association between abnormal thyroid function and depression. The higher rate of thyroid dysfunction in MDD patients indicated the importance of regular monitoring of thyroid function.en_US
dc.identifier.citationZhou Y, Ma Y, Wu Q, Wang Q, Yang WFZ, Wang Y, Yang D, Luo Y, Tang K, Liu T and Wang D (2021) Comparison of Thyroid Hormone Levels Between Patients With Major Depressive Disorder and Healthy Individuals in China. Front. Psychiatry 12:750749. doi: 10.3389/fpsyt.2021.750749en_US
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2021.750749
dc.identifier.urihttps://hdl.handle.net/2346/90275
dc.language.isoengen_US
dc.subjectThyroid Hormonesen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectFT3en_US
dc.subjectFT4en_US
dc.subjectTSHen_US
dc.titleComparison of Thyroid Hormone Levels Between Patients With Major Depressive Disorder and Healthy Individuals in Chinaen_US
dc.typeArticleen_US

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