Natural infection of Neotropical bats with hantavirus in Brazil

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dc.creatorSabino-Santos, Gilberto
dc.creatorMaia, Felipe Gonçalves Motta
dc.creatorMartins, Ronaldo Bragança
dc.creatorGagliardi, Talita Bianca
dc.creatorDe Souza, William Marciel
dc.creatorMuylaert, Renata Lara
dc.creatorLuna, Luciano Kleber De Souza
dc.creatorMelo, Danilo Machado
dc.creatorDe Souza Cardoso, Ricardo
dc.creatorDa Silva Barbosa, Natalia
dc.creatorPontelli, Marjorie Cornejo
dc.creatorMamani-Zapana, Priscila Rosse
dc.creatorVieira, Thallyta Maria
dc.creatorMelo, Norma Maria
dc.creatorJonsson, Colleen B.
dc.creatorGoodin, Douglas
dc.creatorSalazar-Bravo, Jorge (TTU)
dc.creatorDasilva, Luis Lamberti Pinto
dc.creatorArruda, Eurico
dc.creatorFigueiredo, Luiz Tadeu Moraes
dc.date.accessioned2023-07-27T15:04:17Z
dc.date.available2023-07-27T15:04:17Z
dc.date.issued2018
dc.description© 2018 The Author(s). cc-by
dc.description.abstractBats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks.
dc.identifier.citationSabino-Santos, G., Maia, F.G.M., Martins, R.B., Gagliardi, T.B., De, Souza, W.M., Muylaert, R.L., Luna, L.K.D.S., Melo, D.M., De, Souza, Cardoso, R., Da, Silva, Barbosa, N., Pontelli, M.C., Mamani-Zapana, P.R., Vieira, T.M., Melo, N.M., Jonsson, C.B., Goodin, D., Salazar-Bravo, J., Dasilva, L.L.P., Arruda, E., . . . Figueiredo, L.T.M.. 2018. Natural infection of Neotropical bats with hantavirus in Brazil. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-27442-w
dc.identifier.urihttps://doi.org/10.1038/s41598-018-27442-w
dc.identifier.urihttps://hdl.handle.net/2346/95251
dc.language.isoeng
dc.titleNatural infection of Neotropical bats with hantavirus in Brazil
dc.typeArticle

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