Bovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performance

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dc.creatorHergenreder, Jerilyn E.
dc.creatorBaggerman, Jessica O.
dc.creatorHarris, Tyler L.
dc.creatorThompson, Alex J.
dc.creatorSpivey, Kari S.
dc.creatorBroadway, P. Rand
dc.creatorVogel, Gary J.
dc.creatorSmith, Zachary K.
dc.creatorJohnson, Bradley J.
dc.date.accessioned2021-08-11T21:49:27Z
dc.date.available2021-08-11T21:49:27Z
dc.date.issued2021
dc.description© 2021 Hergenreder, et al. This is an open access article distributed under the CC BY license (https://creativecommons.org/licenses/by/4.0/)en_US
dc.description.abstractThe objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase. Heifers (n = 16; initial body weight = 457 ± 3 kg) were randomly assigned to pens (4 pens/treatment; 2 heads/pen) and treatment: (1) no rbST (Control); (2) 500 mg/hd of sometribove zinc at day 0 and 14 (rbST; Posilac®; Elanco AnimalHealth, Greenfield, IN). Longissimus muscle biopsies for muscle chemistry were collected on day 0, 14, 28, 42, and 56. The rbST heifers had increased expression of AMP-activated protein kinase alpha and beta 3 adrenergic receptor (P < 0.05). Day of the study affected the expression of myosin heavy chain-IIA (MHC-IIA), MHC-IIX, beta 2 adrenergic receptor, peroxisome proliferator-activated receptor gamma, and stearoyl-CoA desaturase (P < 0.05). Day had a significant effect on muscle fiber cross-sectional area and proportion (P < 0.05). As days on feed increased, the area of MHC-I fibers decreased whereas MHC-IIA and IIX area increased (P < 0.05). The rbST heifers had decreased proportions of MHC-I fibers and increased proportions of MHC-IIX fibers (P < 0.05). The greatest density of Paired Box 7-positive cells was on day 0, 28, and 42 (P < 0.05), and the greatest density of Myogenic factor 5-positive cells was on day 42 and 56 (P < 0.05). Also, the greatest density of cells positive for Paired Box 7:Myogenic factor 5 was measured on day 28 (P < 0.05). These data indicate that, as days on feed increase, the effects of skeletal muscle biological activity are not dependent on rbST administration but may be more due to physiological changes occurring as the animal reaches physio-logical maturity.en_US
dc.identifier.citationHergenreder J. E. & Baggerman J. O. & Harris T. L. & Thompson A. J. & Spivey K. S. & Broadway P. R. & Vogel G. J. & Smith Z. K. & Johnson B. J., (2021) “Bovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performance”, Meat and Muscle Biology 5(1). p.2, 1–16. doi: https://doi.org/10.22175/mmb.11137en_US
dc.identifier.urihttps://doi.org/10.22175/mmb.11137
dc.identifier.urihttps://hdl.handle.net/2346/87616
dc.language.isoengen_US
dc.subjectRecombinant Bovine Somatotropinen_US
dc.subjectMyosin Heavy Chainen_US
dc.subjectβ-Adrenergic Receptoren_US
dc.titleBovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performanceen_US
dc.typeArticleen_US

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