Browsing by Author "Liu, Yang"
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Item An Optimized Noncontact Vital Signs (NCVS) System for Potential Patient Monitoring Enabled by Robust Software Defined Radio (SDR)(2022-12) Liu, Yang; Lie, Donald; Chong, Jo WoonMonkeypox is starting to spread while COVID_19 is still around, and the seasonal flu also breaks out yearly. As many of these diseases affect the vital signs of the patients such as blood pressure, temperature, respiration rate (RR), and heart rate (HR), these vital signs data will greatly help the medical workers to do the early diagnosis. This paper describes an optimized Software Defined Radio (SRD)-Enable Noncontact Vital Sign (NCVS) system which has the potential to monitor patients heart rate and (HR) respiration rate (RR) remotely with very high accuracy. Dr. Lie’s lab has been on working on this project for several years, and a prototype system was delivered in 2019. The paper begins with the motivation that inspired the project. Next the fundamental principle of the system is described. An illustration about the hardware devices, their setup and software programing is given. The optimization process with experiment results obtained at lab and clinical trial data will be further discussed. Next, a conclusion and the prospect of the system are presented. Finally, test data verifying the integrity of the system is presented along with its use in additional applications.Item Child and Maternal Risk and Protective Factors for Anxiety and Depression in Infancy(2017-11-29) Liu, Yang; Caldera, Yvonne; McCarty, Michael; Oh, WonjungAnxiety is an adaptive response to stressful situations that can be found in all age groups including infants. Infants may experience anxiety when separating from parents, when experiencing a new or unusual situation or loud noises. These anxieties are adaptive and found in most typically developing infants, but in some situations, infants can experience high levels of anxiety and as a result develop Anxiety Disorder later in life. Although Anxiety Disorders have been well described for older children and adults, researchers only recently have started to focus on Anxiety Disorders in toddlers and preschoolers but not many focus on infants. As a result, little is understood about predictors and correlates of Infant Anxiety/Depression (AD) during the first three years of life. The main purpose of this study therefore is to examine child and maternal characteristics as risk and protective factors for AD in 24- and 36-month-old infants. Using data from the National Institute of Child Health and Human Development Early Child Care study, the current study tested the effects of multiple child characteristics and maternal characteristics on Infant AD at 24 and 36 months longitudinally. Further, the current study examined the indirect effect of maternal depression, parenting stress, maternal personality, social support, and infant difficult temperament on Infant Anxiety. This study found that maternal depression occurring concurrently as well as previously was found associated with Infant AD significantly. Parenting stress was more influential on Infant AD at 24 than 36 months. Only maternal sensitivity at 15 months was negatively linked to Infant AD at 24 months, whereas only maternal negativity at 6 months was positively linked to Infant AD at 36 months. Maternal social support was only marginally related to Infant Anxiety. Furthermore, the current study identified an indirect path from parenting stress, maternal social support, maternal personality, and infant difficult temperament to Infant AD via maternal depression. Further Maternal social support and maternal agreeableness measured in the first year also impacted parenting stress in the second year and in turn impacted Infant Anxiety/Depression at 2 years old. Still, Infant AD at 24 months was most predictive of Infant AD at 36 months. These findings suggest the need for alleviating maternal depression and parenting stress in order to prevent the development of anxiety disorder later.Item Genetic variation among 481 diverse soybean accessions, inferred from genomic re-sequencing(2021) Valliyodan, Babu; Brown, Anne V.; Wang, Juexin; Patil, Gunvant (TTU); Liu, Yang; Otyama, Paul I.; Nelson, Rex T.; Vuong, Tri; Song, Qijian; Musket, Theresa A.; Wagner, Ruth; Marri, Pradeep; Reddy, Sam; Sessions, Allen; Wu, Xiaolei; Grant, David; Bayer, Philipp; Roorkiwal, Manish; Varshney, Rajeev K.; Liu, Xin; Edwards, David; Xu, Dong; Joshi, Trupti; Cannon, Steven B.; Nguyen, Henry T.We report characteristics of soybean genetic diversity and structure from the resequencing of 481 diverse soybean accessions, comprising 52 wild (Glycine soja) selections and 429 cultivated (Glycine max) varieties (landraces and elites). This data was used to identify 7.8 million SNPs, to predict SNP effects relative to genic regions, and to identify the genetic structure, relationships, and linkage disequilibrium. We found evidence of distinct, mostly independent selection of lineages by particular geographic location. Among cultivated varieties, we identified numerous highly conserved regions, suggesting selection during domestication. Comparisons of these accessions against the whole U.S. germplasm genotyped with the SoySNP50K iSelect BeadChip revealed that over 95% of the re-sequenced accessions have a high similarity to their SoySNP50K counterparts. Probable errors in seed source or genotype tracking were also identified in approximately 5% of the accessions.Item Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers(2007) Liu, Yang; Gao, Weimin (TTU); Siegfried, Jill M.; Weissfeld, Joel L.; Luketich, James D.; Keohavong, PhouthoneBackground: Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor suppressor genes are frequent in lung tumors from smokers but rare in those from never-smokers. In this study, we analyzed promoter methylation in the ras-association domain isoform A (RASSF1A) and the death-associated protein kinase (DAPK) genes in lung tumors from patients with primarily non-small cell lung cancer (NSCLC) from the Western Pennsylvania region. We compare the results with the smoking status of the patients and the mutation status of the K-ras, p53, and EGFR genes determined previously on these same lung tumors. Methods: Promoter methylation of the RASSF1A and DAPK genes was analyzed by using a modified two-stage methylation-specific PCR. Data on mutations of K-ras, p53, and EGFR were obtained from our previous studies. Results: The RASSF1A gene promoter methylation was found in tumors from 46.7% (57/122) of the patients and was not significantly different between smokers and never-smokers, but was associated significantly in multiple variable analysis with tumor histology (p = 0.031) and marginally with tumor stage (p = 0.063). The DAPK gene promoter methylation frequency in these tumors was 32.8% (40/122) and did not differ according to the patients' smoking status, tumor histology, or tumor stage. Multivariate analysis adjusted for age, gender, smoking status, tumor histology and stage showed that the frequency of promoter methylation of the RASSF1A or DAPK genes did not correlate with the frequency of mutations of the K-ras, p53, and EGFR gene. Conclusion: Our results showed that RASSF1A and DAPK genes' promoter methylation occurred frequently in lung tumors, although the prevalence of this alteration in these genes was not associated with the smoking status of the patients or the occurrence of mutations in the K-ras, p53 and EGFR genes, suggesting each of these events may represent independent event in non-small lung tumorigenesis. © 2007 Liu et al; licensee BioMed Central Ltd.Item Resolution of the ordinal phylogeny of mosses using targeted exons from organellar and nuclear genomes(2019) Liu, Yang; Johnson, Matthew G. (TTU); Cox, Cymon J.; Medina, Rafael; Devos, Nicolas; Vanderpoorten, Alain; Hedenäs, Lars; Bell, Neil E.; Shevock, James R.; Aguero, Blanka; Quandt, Dietmar; Wickett, Norman J.; Shaw, A. Jonathan; Goffinet, BernardMosses are a highly diverse lineage of land plants, whose diversification, spanning at least 400 million years, remains phylogenetically ambiguous due to the lack of fossils, massive early extinctions, late radiations, limited morphological variation, and conflicting signal among previously used markers. Here, we present phylogenetic reconstructions based on complete organellar exomes and a comparable set of nuclear genes for this major lineage of land plants. Our analysis of 142 species representing 29 of the 30 moss orders reveals that relative average rates of non-synonymous substitutions in nuclear versus plastid genes are much higher in mosses than in seed plants, consistent with the emerging concept of evolutionary dynamism in mosses. Our results highlight the evolutionary significance of taxa with reduced morphologies, shed light on the relative tempo and mechanisms underlying major cladogenic events, and suggest hypotheses for the relationships and delineation of moss orders.