Specialized Ribosomes in Health and Disease

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dc.creatorMiller, Sarah C. (TTUHSC)
dc.creatorMacDonald, Clinton C. (TTUHSC)
dc.creatorKellogg, Morgana K. (TTUHSC)
dc.creatorKaramysheva, Zemfira N. (TTU)
dc.creatorKaramyshev, Andrey L. (TTUHSC)
dc.date.accessioned2023-05-12T18:16:45Z
dc.date.available2023-05-12T18:16:45Z
dc.date.issued2023
dc.description© 2023 by the authors. cc-by
dc.description.abstractRibosomal heterogeneity exists within cells and between different cell types, at specific developmental stages, and occurs in response to environmental stimuli. Mounting evidence supports the existence of specialized ribosomes, or specific changes to the ribosome that regulate the translation of a specific group of transcripts. These alterations have been shown to affect the affinity of ribosomes for certain mRNAs or change the cotranslational folding of nascent polypeptides at the exit tunnel. The identification of specialized ribosomes requires evidence of the incorporation of different ribosomal proteins or of modifications to rRNA and/or protein that lead(s) to physiologically relevant changes in translation. In this review, we summarize ribosomal heterogeneity and specialization in mammals and discuss their relevance to several human diseases.
dc.identifier.citationMiller, S.C., MacDonald, C.C., Kellogg, M.K., Karamysheva, Z.N., & Karamyshev, A.L.. 2023. Specialized Ribosomes in Health and Disease. International Journal of Molecular Sciences, 24(7). https://doi.org/10.3390/ijms24076334
dc.identifier.urihttps://doi.org/10.3390/ijms24076334
dc.identifier.urihttps://hdl.handle.net/2346/93531
dc.language.isoeng
dc.subjecthuman disease
dc.subjectprotein synthesis
dc.subjectribosomal protein
dc.subjectribosomal RNA
dc.subjectribosome heterogeneity
dc.subjectribosome specialization
dc.subjecttranslation
dc.subjecttranslational control
dc.titleSpecialized Ribosomes in Health and Disease
dc.typeReview

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